Prolyl hydroxylase
From Wikipedia, the free encyclopedia
Prolyl hydroxylase (or procollagen-proline dioxygenase) is an enzyme involved in the production of collagen, acting to hydroxylate proline to hydroxyproline.
It requires vitamin C as a cofactor.
Reaction: Proline + α-ketoglutarate + O2 + Fe2+ → 4-hydroxyproline + Fe3+ + CO2 + succinate
The process requires ascorbic acid which provides Fe2+as a reductant to release two electrons.
It is classified under EC 1.14.11.2.
The Fe2+ is oxidized to 3+ state, not 4+ in the hydroxylase reaction
[edit] External links
|
||||||||||||||||||||||||||
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
||||||||||||||||||||||||||||||||||||||||||||
